Drug interactions
Orphenadrin + Tolterodine
Severity: Moderate
Orphenadrin and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, increasing total anticholinergic load. This may cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older people.
What this interaction means in plain words
Orphenadrin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Tolterodine belongs to Genitourinary.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects and cognitive changes. Consider an alternative to one drug in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Tolterodine
Frequently asked questions
Can I take Orphenadrin with Tolterodine?
MediHelp rates the interaction as moderate. Orphenadrin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, increasing total anticholinergic load. This may cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older people.
How serious is the interaction between Orphenadrin and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and cognitive changes. Consider an alternative to one drug in older patients.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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