Drug interactions
Orphenadrine + Solifenacin
Severity: Moderate
Orphenadrine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has strong anticholinergic properties, so adding solifenacin increases dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are at greater risk.
What this interaction means in plain words
Orphenadrine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid the combination in older patients or those with retention or glaucoma; otherwise monitor for anticholinergic toxicity and reduce doses if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Orphenadrine with Solifenacin?
MediHelp rates the interaction as moderate. Orphenadrine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has strong anticholinergic properties, so adding solifenacin increases dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are at greater risk.
How serious is the interaction between Orphenadrine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients or those with retention or glaucoma; otherwise monitor for anticholinergic toxicity and reduce doses if it occurs.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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