Drug interactions
Osilodrostat + Phenytoin
Severity: Moderate
Osilodrostat and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may reduce osilodrostat exposure, which can lead to inadequate cortisol control in Cushing's disease.
What this interaction means in plain words
Osilodrostat and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and CYP2B6 by phenytoin increases the metabolism of osilodrostat.
What to do
Monitor cortisol levels and clinical features, and increase the osilodrostat dose if needed. Reassess the dose when phenytoin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Phenytoin?
MediHelp rates the interaction as moderate. Osilodrostat and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin may reduce osilodrostat exposure, which can lead to inadequate cortisol control in Cushing's disease.
How serious is the interaction between Osilodrostat and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels and clinical features, and increase the osilodrostat dose if needed. Reassess the dose when phenytoin is discontinued.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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