Drug interactions
Osilodrostat + Salbutamol
Severity: Moderate
Osilodrostat and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and salbutamol can also contribute to QT prolongation and hypokalemia, particularly at high doses. Together they may raise the risk of ventricular arrhythmia.
What this interaction means in plain words
Osilodrostat and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Salbutamol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization, with salbutamol-induced hypokalemia increasing susceptibility.
What to do
Obtain a baseline ECG and monitor QTc and serum potassium and magnesium, correcting abnormalities. Avoid excessive salbutamol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Salbutamol?
MediHelp rates the interaction as moderate. Osilodrostat and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and salbutamol can also contribute to QT prolongation and hypokalemia, particularly at high doses. Together they may raise the risk of ventricular arrhythmia.
How serious is the interaction between Osilodrostat and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and serum potassium and magnesium, correcting abnormalities. Avoid excessive salbutamol dosing.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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