Drug interactions
Osilodrostat + Terbutaline
Severity: Moderate
Osilodrostat and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and terbutaline may do so as well, particularly through hypokalemia and tachycardia at higher doses. Together they may raise the risk of ventricular arrhythmias, especially with electrolyte disturbance or underlying heart disease.
What this interaction means in plain words
Osilodrostat and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Terbutaline belongs to Respiratory.
Why it happens
Additive QT prolongation, with terbutaline-induced hypokalemia as a contributing factor.
What to do
Check ECG and correct potassium and magnesium before and during therapy. Monitor QTc, especially when terbutaline is used at higher or systemic doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Terbutaline?
MediHelp rates the interaction as moderate. Osilodrostat and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and terbutaline may do so as well, particularly through hypokalemia and tachycardia at higher doses. Together they may raise the risk of ventricular arrhythmias, especially with electrolyte disturbance or underlying heart disease.
How serious is the interaction between Osilodrostat and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during therapy. Monitor QTc, especially when terbutaline is used at higher or systemic doses.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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