Drug interactions
Osilodrostat + Theophylline
Severity: Moderate
Osilodrostat and Theophylline: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat may inhibit CYP1A2, the main route of theophylline elimination, which could raise theophylline concentrations. Labeling advises caution with sensitive CYP1A2 substrates.
What this interaction means in plain words
Osilodrostat and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Theophylline belongs to Respiratory.
Why it happens
Osilodrostat inhibits CYP1A2, reducing theophylline clearance.
What to do
Monitor theophylline concentrations and signs of toxicity when starting osilodrostat, and reduce the theophylline dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Isturisa - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Theophylline?
MediHelp rates the interaction as moderate. Osilodrostat and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat may inhibit CYP1A2, the main route of theophylline elimination, which could raise theophylline concentrations. Labeling advises caution with sensitive CYP1A2 substrates.
How serious is the interaction between Osilodrostat and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline concentrations and signs of toxicity when starting osilodrostat, and reduce the theophylline dose if needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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