Drug interactions
Osimertinib + Pimozide
Severity: Major
Osimertinib and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias including torsades de pointes. Osimertinib is also a weak CYP3A4 inducer that could slightly reduce pimozide exposure.
What this interaction means in plain words
Osimertinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osimertinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Avoid the combination if possible, or monitor ECG and electrolytes periodically and correct hypokalemia and hypomagnesemia. Discontinue osimertinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Pimozide?
MediHelp rates the interaction as major. Osimertinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias including torsades de pointes. Osimertinib is also a weak CYP3A4 inducer that could slightly reduce pimozide exposure.
How serious is the interaction between Osimertinib and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor ECG and electrolytes periodically and correct hypokalemia and hypomagnesemia. Discontinue osimertinib if QTc becomes markedly prolonged.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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