Drug interactions
Osimertinib + Salbutamol
Severity: Moderate
Osimertinib and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is associated with QT prolongation, and high-dose salbutamol can add to this through hypokalemia and direct cardiac effects. The combined effect is usually modest but matters in patients with other arrhythmia risks.
What this interaction means in plain words
Osimertinib and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 mediated hypokalemia as a contributor.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors or on frequent salbutamol. Correct potassium and magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Osimertinib and Salbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Salbutamol
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Salbutamol?
MediHelp rates the interaction as moderate. Osimertinib and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib is associated with QT prolongation, and high-dose salbutamol can add to this through hypokalemia and direct cardiac effects. The combined effect is usually modest but matters in patients with other arrhythmia risks.
How serious is the interaction between Osimertinib and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors or on frequent salbutamol. Correct potassium and magnesium deficits.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
