Drug interactions
Oteseconazole + Pitavastatin
Severity: Moderate
Oteseconazole and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and can increase exposure to BCRP substrates including pitavastatin. This raises the risk of dose-related statin adverse effects such as myopathy.
What this interaction means in plain words
Oteseconazole and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oteseconazole belongs to Anti Fungals; Pitavastatin belongs to Cardiovascular.
Why it happens
BCRP inhibition by oteseconazole decreases efflux of pitavastatin.
What to do
Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Oteseconazole has a very long half-life, so the interaction may persist after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Oteseconazole with Pitavastatin?
MediHelp rates the interaction as moderate. Oteseconazole and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP and can increase exposure to BCRP substrates including pitavastatin. This raises the risk of dose-related statin adverse effects such as myopathy.
How serious is the interaction between Oteseconazole and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Oteseconazole has a very long half-life, so the interaction may persist after stopping.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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