Drug interactions
Oxaliplatin + Paclitaxel protein bound
Severity: Moderate
Oxaliplatin and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause myelosuppression and peripheral neuropathy. Combined use can increase the severity of neutropenia and sensory neuropathy, raising infection risk and functional impairment.
What this interaction means in plain words
Oxaliplatin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic bone marrow suppression and neurotoxicity.
What to do
Monitor blood counts and neuropathy symptoms at each cycle and reduce doses for grade 3 toxicity. Give the taxane before oxaliplatin when infused sequentially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Oxaliplatin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause myelosuppression and peripheral neuropathy. Combined use can increase the severity of neutropenia and sensory neuropathy, raising infection risk and functional impairment.
How serious is the interaction between Oxaliplatin and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms at each cycle and reduce doses for grade 3 toxicity. Give the taxane before oxaliplatin when infused sequentially.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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