Drug interactions
Oxaliplatin + Peramivir
Severity: Minor
Oxaliplatin and Peramivir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is cleared almost entirely by the kidneys, and oxaliplatin can impair renal function in some patients. Reduced renal function could raise peramivir exposure, but oxaliplatin is only mildly nephrotoxic and peramivir has a wide safety margin.
What this interaction means in plain words
Oxaliplatin and Peramivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduced renal clearance of peramivir if oxaliplatin causes renal impairment.
What to do
Check renal function and adjust peramivir dose according to creatinine clearance as per labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Peramivir?
MediHelp rates the interaction as minor. Oxaliplatin and Peramivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peramivir is cleared almost entirely by the kidneys, and oxaliplatin can impair renal function in some patients. Reduced renal function could raise peramivir exposure, but oxaliplatin is only mildly nephrotoxic and peramivir has a wide safety margin.
How serious is the interaction between Oxaliplatin and Peramivir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function and adjust peramivir dose according to creatinine clearance as per labeling.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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