Drug interactions
Oxaliplatin + Pneumococcal vaccine heptavalent
Severity: Moderate
Oxaliplatin and Pneumococcal vaccine heptavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with oxaliplatin can lower the antibody response to pneumococcal conjugate vaccine. This matters because cancer patients are at increased risk of invasive pneumococcal disease.
What this interaction means in plain words
Oxaliplatin and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
Give pneumococcal vaccine at least 2 weeks before chemotherapy when possible; if given within 14 days before or during treatment, revaccinate about 3 months after therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Pneumococcal vaccine heptavalent?
MediHelp rates the interaction as moderate. Oxaliplatin and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with oxaliplatin can lower the antibody response to pneumococcal conjugate vaccine. This matters because cancer patients are at increased risk of invasive pneumococcal disease.
How serious is the interaction between Oxaliplatin and Pneumococcal vaccine heptavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pneumococcal vaccine at least 2 weeks before chemotherapy when possible; if given within 14 days before or during treatment, revaccinate about 3 months after therapy ends.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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