Drug interactions
Oxaliplatin + Poliovirus vaccine inactivated
Severity: Minor
Oxaliplatin and Poliovirus vaccine inactivated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin chemotherapy may lead to a suboptimal antibody response to inactivated poliovirus vaccine. Because the vaccine is not live, it is safe, but immunity may be incomplete.
What this interaction means in plain words
Oxaliplatin and Poliovirus vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
Where possible, give doses before chemotherapy or defer until after immune recovery; revaccinate at least 3 months after therapy if doses were given during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Poliovirus vaccine inactivated?
MediHelp rates the interaction as minor. Oxaliplatin and Poliovirus vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxaliplatin chemotherapy may lead to a suboptimal antibody response to inactivated poliovirus vaccine. Because the vaccine is not live, it is safe, but immunity may be incomplete.
How serious is the interaction between Oxaliplatin and Poliovirus vaccine inactivated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give doses before chemotherapy or defer until after immune recovery; revaccinate at least 3 months after therapy if doses were given during treatment.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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