Drug interactions
Oxaliplatin + Procainamide
Severity: Major
Oxaliplatin and Procainamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide is a class IA antiarrhythmic with a known risk of QT prolongation and torsades de pointes. Oxaliplatin may add to this risk, particularly when electrolytes are disturbed.
What this interaction means in plain words
Oxaliplatin and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Avoid if alternatives exist. If both are needed, monitor ECG and electrolytes and adjust procainamide dosing based on QRS and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Procainamide?
MediHelp rates the interaction as major. Oxaliplatin and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procainamide is a class IA antiarrhythmic with a known risk of QT prolongation and torsades de pointes. Oxaliplatin may add to this risk, particularly when electrolytes are disturbed.
How serious is the interaction between Oxaliplatin and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist. If both are needed, monitor ECG and electrolytes and adjust procainamide dosing based on QRS and QTc.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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