Drug interactions
Oxaliplatin + Rabies vaccine
Severity: Moderate
Oxaliplatin and Rabies vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy may impair the antibody response to rabies vaccine. In post-exposure or pre-exposure settings, inadequate titers could leave the patient unprotected against a fatal disease.
What this interaction means in plain words
Oxaliplatin and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
For post-exposure prophylaxis, never withhold treatment, add immune globulin as indicated, and check rabies neutralizing antibody titers afterward; for pre-exposure vaccination, give before chemotherapy when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Rabies vaccine?
MediHelp rates the interaction as moderate. Oxaliplatin and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy may impair the antibody response to rabies vaccine. In post-exposure or pre-exposure settings, inadequate titers could leave the patient unprotected against a fatal disease.
How serious is the interaction between Oxaliplatin and Rabies vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For post-exposure prophylaxis, never withhold treatment, add immune globulin as indicated, and check rabies neutralizing antibody titers afterward; for pre-exposure vaccination, give before chemotherapy when feasible.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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