Drug interactions
Oxaliplatin + Rotavirus oral vaccine live
Severity: Contraindicated
Oxaliplatin and Rotavirus oral vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin causes myelosuppression and immunosuppression, so a live-attenuated vaccine may replicate unchecked and cause vaccine-strain disease. The vaccine response may also be blunted. In practice, rotavirus vaccine is given to infants, so this pairing is rarely relevant.
What this interaction means in plain words
Oxaliplatin and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Chemotherapy-induced immunosuppression impairs control of live vaccine organisms and reduces the immune response to the vaccine.
What to do
Do not give live vaccines during oxaliplatin therapy. Delay live vaccination until immune recovery, generally at least 3 months after chemotherapy ends, and follow local immunization guidance.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Rotavirus oral vaccine live?
MediHelp rates the interaction as contraindicated. Oxaliplatin and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxaliplatin causes myelosuppression and immunosuppression, so a live-attenuated vaccine may replicate unchecked and cause vaccine-strain disease. The vaccine response may also be blunted. In practice, rotavirus vaccine is given to infants, so this pairing is rarely relevant.
How serious is the interaction between Oxaliplatin and Rotavirus oral vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during oxaliplatin therapy. Delay live vaccination until immune recovery, generally at least 3 months after chemotherapy ends, and follow local immunization guidance.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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