Drug interactions
Oxaliplatin + Smallpox vaccine live
Severity: Contraindicated
Oxaliplatin and Smallpox vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live vaccinia vaccine can cause progressive vaccinia and serious generalized infection in immunocompromised people. Oxaliplatin-related immunosuppression raises this risk and may also reduce protective immunity.
What this interaction means in plain words
Oxaliplatin and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Chemotherapy-induced immunosuppression allows uncontrolled replication of live vaccinia virus and weakens the immune response.
What to do
Avoid live smallpox vaccine during oxaliplatin therapy and for about 3 months afterwards. If exposure risk is high, seek infectious disease or public health advice on alternatives.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Oxaliplatin and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and serious generalized infection in immunocompromised people. Oxaliplatin-related immunosuppression raises this risk and may also reduce protective immunity.
How serious is the interaction between Oxaliplatin and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine during oxaliplatin therapy and for about 3 months afterwards. If exposure risk is high, seek infectious disease or public health advice on alternatives.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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