Drug interactions
Oxaliplatin + Tenofovir df
Severity: Moderate
Oxaliplatin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil can cause proximal tubular injury, and both drugs are renally eliminated. Reduced kidney function could increase exposure to tenofovir and platinum species, although oxaliplatin is only mildly nephrotoxic.
What this interaction means in plain words
Oxaliplatin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal tubular injury and competition or reduction in renal elimination.
What to do
Monitor serum creatinine, phosphate and urinalysis regularly and adjust tenofovir dosing for creatinine clearance. Consider an alternative such as tenofovir alafenamide if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Tenofovir df?
MediHelp rates the interaction as moderate. Oxaliplatin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil can cause proximal tubular injury, and both drugs are renally eliminated. Reduced kidney function could increase exposure to tenofovir and platinum species, although oxaliplatin is only mildly nephrotoxic.
How serious is the interaction between Oxaliplatin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinalysis regularly and adjust tenofovir dosing for creatinine clearance. Consider an alternative such as tenofovir alafenamide if renal function declines.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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