Drug interactions
Oxaliplatin + Tenofovir disoproxil
Severity: Moderate
Oxaliplatin and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and oxaliplatin is cleared partly by the kidney. Combined use may worsen renal function, and impaired renal function can in turn raise tenofovir exposure and the risk of tubular toxicity.
What this interaction means in plain words
Oxaliplatin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with reduced renal function secondarily lowering tenofovir elimination.
What to do
Monitor serum creatinine, phosphate and estimated creatinine clearance before and during oxaliplatin cycles. Consider an alternative antiretroviral if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Oxaliplatin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and oxaliplatin is cleared partly by the kidney. Combined use may worsen renal function, and impaired renal function can in turn raise tenofovir exposure and the risk of tubular toxicity.
How serious is the interaction between Oxaliplatin and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and estimated creatinine clearance before and during oxaliplatin cycles. Consider an alternative antiretroviral if renal function declines.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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