Drug interactions
Oxaliplatin + Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine
Severity: Minor
Oxaliplatin and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with oxaliplatin may reduce the antibody response to Tdap vaccine. Protective titers against tetanus, diphtheria and pertussis may be lower than expected.
What this interaction means in plain words
Oxaliplatin and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
Give the vaccine at least 2 weeks before chemotherapy when possible; for wounds during treatment, give tetanus prophylaxis as indicated and consider revaccination after immune recovery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as minor. Oxaliplatin and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chemotherapy with oxaliplatin may reduce the antibody response to Tdap vaccine. Protective titers against tetanus, diphtheria and pertussis may be lower than expected.
How serious is the interaction between Oxaliplatin and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before chemotherapy when possible; for wounds during treatment, give tetanus prophylaxis as indicated and consider revaccination after immune recovery.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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