Drug interactions
Oxaliplatin + Tobramycin inhaled
Severity: Moderate
Oxaliplatin and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can damage the kidney and inner ear, though systemic exposure to inhaled tobramycin is low. Additive nephrotoxicity or ototoxicity is possible, especially with renal impairment or prolonged use.
What this interaction means in plain words
Oxaliplatin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic and ototoxic effects of a platinum agent and an aminoglycoside.
What to do
Monitor serum creatinine and ask about hearing changes or tinnitus; consider audiometry if the combination is prolonged, and avoid additional nephrotoxins.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Oxaliplatin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can damage the kidney and inner ear, though systemic exposure to inhaled tobramycin is low. Additive nephrotoxicity or ototoxicity is possible, especially with renal impairment or prolonged use.
How serious is the interaction between Oxaliplatin and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and ask about hearing changes or tinnitus; consider audiometry if the combination is prolonged, and avoid additional nephrotoxins.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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