Drug interactions
Oxaliplatin + Trifluoperazine
Severity: Moderate
Oxaliplatin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin is associated with QT prolongation, and trifluoperazine, a phenothiazine, can also prolong the QT interval. The combination may increase arrhythmia risk, particularly with electrolyte disturbance from chemotherapy-induced vomiting or diarrhea.
What this interaction means in plain words
Oxaliplatin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check baseline ECG and keep potassium and magnesium within normal range. Consider an antiemetic alternative with less QT effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Trifluoperazine?
MediHelp rates the interaction as moderate. Oxaliplatin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin is associated with QT prolongation, and trifluoperazine, a phenothiazine, can also prolong the QT interval. The combination may increase arrhythmia risk, particularly with electrolyte disturbance from chemotherapy-induced vomiting or diarrhea.
How serious is the interaction between Oxaliplatin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and keep potassium and magnesium within normal range. Consider an antiemetic alternative with less QT effect.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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