Drug interactions
Oxaliplatin + Trifluridine / tipiracil
Severity: Moderate
Oxaliplatin and Trifluridine / tipiracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, so combined use can deepen neutropenia and other cytopenias and increase the risk of serious infection. This combination is used in some regimens but needs careful hematologic supervision.
What this interaction means in plain words
Oxaliplatin and Trifluridine / tipiracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts before each cycle and during treatment. Delay doses or reduce them for severe neutropenia, and give prompt treatment for febrile neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Trifluridine / tipiracil?
MediHelp rates the interaction as moderate. Oxaliplatin and Trifluridine / tipiracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, so combined use can deepen neutropenia and other cytopenias and increase the risk of serious infection. This combination is used in some regimens but needs careful hematologic supervision.
How serious is the interaction between Oxaliplatin and Trifluridine / tipiracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each cycle and during treatment. Delay doses or reduce them for severe neutropenia, and give prompt treatment for febrile neutropenia.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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