Drug interactions
Oxaliplatin + Typhoid polysaccharide vaccine
Severity: Moderate
Oxaliplatin and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The Vi polysaccharide typhoid vaccine is inactivated and not infectious, so there is no infection risk. However, oxaliplatin may reduce the antibody response and leave the patient less protected.
What this interaction means in plain words
Oxaliplatin and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces the immune response to the inactivated vaccine.
What to do
Where possible give the vaccine at least 2 weeks before starting chemotherapy, or after immune recovery. If given during treatment, consider revaccination later if protection is still needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Oxaliplatin and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The Vi polysaccharide typhoid vaccine is inactivated and not infectious, so there is no infection risk. However, oxaliplatin may reduce the antibody response and leave the patient less protected.
How serious is the interaction between Oxaliplatin and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible give the vaccine at least 2 weeks before starting chemotherapy, or after immune recovery. If given during treatment, consider revaccination later if protection is still needed.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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