Drug interactions
Oxaliplatin + Yellow fever vaccine
Severity: Contraindicated
Oxaliplatin and Yellow fever vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is live attenuated and carries a risk of vaccine-associated viscerotropic or neurotropic disease in immunocompromised patients. Oxaliplatin-induced immunosuppression increases this risk and may reduce protection.
What this interaction means in plain words
Oxaliplatin and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Chemotherapy-induced immunosuppression impairs control of live vaccine virus and weakens the immune response.
What to do
Avoid yellow fever vaccine during oxaliplatin therapy. If travel to an endemic area is unavoidable, seek specialist advice and consider a medical exemption letter.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Oxaliplatin and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Yellow fever vaccine is live attenuated and carries a risk of vaccine-associated viscerotropic or neurotropic disease in immunocompromised patients. Oxaliplatin-induced immunosuppression increases this risk and may reduce protection.
How serious is the interaction between Oxaliplatin and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yellow fever vaccine during oxaliplatin therapy. If travel to an endemic area is unavoidable, seek specialist advice and consider a medical exemption letter.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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