Drug interactions
Oxaliplatin + Zoster vaccine recombinant
Severity: Minor
Oxaliplatin and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy may blunt the response to recombinant zoster vaccine, although the vaccine is non-live and generally immunogenic in immunocompromised patients. A lower response may reduce protection against shingles.
What this interaction means in plain words
Oxaliplatin and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
Vaccinate before chemotherapy if possible, but the recombinant vaccine may be given during or after treatment; complete the two-dose series.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Oxaliplatin and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chemotherapy may blunt the response to recombinant zoster vaccine, although the vaccine is non-live and generally immunogenic in immunocompromised patients. A lower response may reduce protection against shingles.
How serious is the interaction between Oxaliplatin and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy if possible, but the recombinant vaccine may be given during or after treatment; complete the two-dose series.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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