Drug interactions
Oxandrolone + Tacrolimus
Severity: Moderate
Oxandrolone and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anabolic steroids may increase tacrolimus levels and thereby the risk of toxicity. Evidence is sparse and mainly extrapolated.
What this interaction means in plain words
Oxandrolone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible reduction of tacrolimus metabolism; the mechanism is not firmly established.
What to do
Monitor tacrolimus trough levels and renal function when oxandrolone is started or stopped, and adjust the tacrolimus dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Oxandrolone with Tacrolimus?
MediHelp rates the interaction as moderate. Oxandrolone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anabolic steroids may increase tacrolimus levels and thereby the risk of toxicity. Evidence is sparse and mainly extrapolated.
How serious is the interaction between Oxandrolone and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when oxandrolone is started or stopped, and adjust the tacrolimus dose.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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