Drug interactions
Oxaprozin + Paroxetine
Severity: Moderate
Oxaprozin and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of an NSAID and an SSRI raises the risk of bleeding, notably in the upper gastrointestinal tract. The risk is higher in older adults and in those with prior GI bleeding or other antithrombotics.
What this interaction means in plain words
Oxaprozin and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRI depletion of platelet serotonin impairs platelet aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Avoid the combination where an alternative analgesic is feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Oxaprozin with Paroxetine?
MediHelp rates the interaction as moderate. Oxaprozin and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of an NSAID and an SSRI raises the risk of bleeding, notably in the upper gastrointestinal tract. The risk is higher in older adults and in those with prior GI bleeding or other antithrombotics.
How serious is the interaction between Oxaprozin and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Avoid the combination where an alternative analgesic is feasible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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