Drug interactions
Oxaprozin + Spironolactone
Severity: Major
Oxaprozin and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of spironolactone and impair renal function, while both promote potassium retention. This increases the risk of hyperkalemia and acute kidney injury, especially in older patients, heart failure or CKD.
What this interaction means in plain words
Oxaprozin and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaprozin belongs to Musculoskeletal; Spironolactone belongs to Cardiovascular.
Why it happens
NSAIDs inhibit renal prostaglandins, reducing renal blood flow and aldosterone-related potassium excretion, adding to aldosterone antagonism.
What to do
Avoid regular NSAID use with spironolactone where possible. If used, monitor serum potassium, creatinine and blood pressure or volume status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Oxaprozin with Spironolactone?
MediHelp rates the interaction as major. Oxaprozin and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can blunt the diuretic and antihypertensive effect of spironolactone and impair renal function, while both promote potassium retention. This increases the risk of hyperkalemia and acute kidney injury, especially in older patients, heart failure or CKD.
How serious is the interaction between Oxaprozin and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with spironolactone where possible. If used, monitor serum potassium, creatinine and blood pressure or volume status closely.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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