Drug interactions
Oxaprozin + Streptomycin
Severity: Moderate
Oxaprozin and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce aminoglycoside clearance, raising levels and risk of nephrotoxicity and ototoxicity. This is mainly reported in preterm infants, and NSAIDs may harm kidneys in at-risk adults.
What this interaction means in plain words
Oxaprozin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins lowers glomerular filtration and aminoglycoside excretion.
What to do
Monitor renal function and streptomycin levels or auditory and vestibular symptoms when combined. Avoid the NSAID where possible in renal impairment or neonates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Oxaprozin with Streptomycin?
MediHelp rates the interaction as moderate. Oxaprozin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce aminoglycoside clearance, raising levels and risk of nephrotoxicity and ototoxicity. This is mainly reported in preterm infants, and NSAIDs may harm kidneys in at-risk adults.
How serious is the interaction between Oxaprozin and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels or auditory and vestibular symptoms when combined. Avoid the NSAID where possible in renal impairment or neonates.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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