Drug interactions
Oxaprozin + Timolol
Severity: Moderate
Oxaprozin and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin may reduce the blood pressure lowering effect of oral timolol with sustained use. Blood pressure control can worsen.
What this interaction means in plain words
Oxaprozin and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis and sodium and water retention antagonize beta-blocker effect.
What to do
Monitor blood pressure when oxaprozin is started, changed or stopped and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Oxaprozin with Timolol?
MediHelp rates the interaction as moderate. Oxaprozin and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin may reduce the blood pressure lowering effect of oral timolol with sustained use. Blood pressure control can worsen.
How serious is the interaction between Oxaprozin and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when oxaprozin is started, changed or stopped and adjust antihypertensive therapy if needed.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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