Drug interactions
Oxaprozin + Tobramycin
Severity: Moderate
Oxaprozin and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of tobramycin, increasing exposure and the risk of nephrotoxicity and ototoxicity. The effect was described mainly in preterm infants, but NSAID renal effects also matter in at-risk adults.
What this interaction means in plain words
Oxaprozin and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandin synthesis decreases glomerular filtration and aminoglycoside clearance.
What to do
Monitor tobramycin serum concentrations and creatinine when an NSAID is co-administered. Avoid the NSAID in neonates, older adults or renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Oxaprozin with Tobramycin?
MediHelp rates the interaction as moderate. Oxaprozin and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of tobramycin, increasing exposure and the risk of nephrotoxicity and ototoxicity. The effect was described mainly in preterm infants, but NSAID renal effects also matter in at-risk adults.
How serious is the interaction between Oxaprozin and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin serum concentrations and creatinine when an NSAID is co-administered. Avoid the NSAID in neonates, older adults or renal impairment where possible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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