Drug interactions
Oxaprozin + Triamterene
Severity: Major
Oxaprozin and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining NSAIDs with triamterene raises the risk of hyperkalemia and acute kidney injury, and this combination has been associated with nephrotoxicity. The diuretic effect may also be reduced.
What this interaction means in plain words
Oxaprozin and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaprozin belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
NSAIDs reduce renal prostaglandin synthesis and perfusion, and triamterene blocks epithelial sodium channels to reduce potassium excretion.
What to do
Avoid the combination where possible. If used, monitor serum potassium and renal function, and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Oxaprozin with Triamterene?
MediHelp rates the interaction as major. Oxaprozin and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining NSAIDs with triamterene raises the risk of hyperkalemia and acute kidney injury, and this combination has been associated with nephrotoxicity. The diuretic effect may also be reduced.
How serious is the interaction between Oxaprozin and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor serum potassium and renal function, and ensure adequate hydration.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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