Drug interactions
Oxaprozin + Valsartan
Severity: Moderate
Oxaprozin and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin can blunt the blood pressure lowering effect of valsartan. In elderly or volume-depleted patients the combination may cause acute kidney injury and raise potassium.
What this interaction means in plain words
Oxaprozin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Valsartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins combined with angiotensin receptor blockade reduces glomerular filtration and promotes sodium retention and hyperkalemia.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the NSAID, and ensure adequate hydration. Use the shortest NSAID course possible or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Oxaprozin with Valsartan?
MediHelp rates the interaction as moderate. Oxaprozin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin can blunt the blood pressure lowering effect of valsartan. In elderly or volume-depleted patients the combination may cause acute kidney injury and raise potassium.
How serious is the interaction between Oxaprozin and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the NSAID, and ensure adequate hydration. Use the shortest NSAID course possible or choose an alternative analgesic.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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