Drug interactions
Oxazepam + Ramelteon
Severity: Minor
Oxazepam and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon can cause somnolence and dizziness, which may add modestly to oxazepam effects. Clinically significant interaction is uncommon and no pharmacokinetic interaction is expected.
What this interaction means in plain words
Oxazepam and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxazepam belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Mild additive sedation from melatonin receptor agonism and benzodiazepine GABA-A potentiation.
What to do
No dose adjustment is generally needed; counsel patients about additive drowsiness and avoiding driving after dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Oxazepam with Ramelteon?
MediHelp rates the interaction as minor. Oxazepam and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon can cause somnolence and dizziness, which may add modestly to oxazepam effects. Clinically significant interaction is uncommon and no pharmacokinetic interaction is expected.
How serious is the interaction between Oxazepam and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; counsel patients about additive drowsiness and avoiding driving after dosing.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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