Drug interactions
Oxazepam + Ziprasidone
Severity: Moderate
Oxazepam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs can cause additive sedation, dizziness and orthostatic hypotension. Ziprasidone also prolongs the QT interval, though oxazepam does not contribute to that effect.
What this interaction means in plain words
Oxazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxazepam belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and ziprasidone antagonism of histamine and alpha-1 adrenergic receptors.
What to do
Monitor for sedation and orthostatic hypotension and use low initial doses. Continue standard QT risk assessment for ziprasidone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Oxazepam with Ziprasidone?
MediHelp rates the interaction as moderate. Oxazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs can cause additive sedation, dizziness and orthostatic hypotension. Ziprasidone also prolongs the QT interval, though oxazepam does not contribute to that effect.
How serious is the interaction between Oxazepam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension and use low initial doses. Continue standard QT risk assessment for ziprasidone.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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