Drug interactions
Oxcarbazepine + Paclitaxel
Severity: Moderate
Oxcarbazepine and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce paclitaxel exposure and possibly its efficacy. Evidence is largely theoretical and extrapolated from stronger inducers.
What this interaction means in plain words
Oxcarbazepine and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Paclitaxel belongs to Oncology.
Why it happens
Oxcarbazepine induces CYP3A4, which contributes to paclitaxel metabolism.
What to do
Use a non-inducing antiepileptic when feasible. Otherwise monitor tumor response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Oxcarbazepine with Paclitaxel?
MediHelp rates the interaction as moderate. Oxcarbazepine and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce paclitaxel exposure and possibly its efficacy. Evidence is largely theoretical and extrapolated from stronger inducers.
How serious is the interaction between Oxcarbazepine and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antiepileptic when feasible. Otherwise monitor tumor response and toxicity.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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