Drug interactions
Oxcarbazepine + Prednisone
Severity: Moderate
Oxcarbazepine and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak-to-moderate CYP3A4 inducer and may lower exposure to prednisolone, potentially reducing corticosteroid efficacy. The effect is less pronounced than with carbamazepine or phenytoin.
What this interaction means in plain words
Oxcarbazepine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Prednisone belongs to Endocrine.
Why it happens
Induction of CYP3A4 increasing metabolic clearance of prednisone/prednisolone.
What to do
Monitor clinical response to prednisone and increase the dose if disease control worsens; reassess when oxcarbazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Prednisone?
MediHelp rates the interaction as moderate. Oxcarbazepine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak-to-moderate CYP3A4 inducer and may lower exposure to prednisolone, potentially reducing corticosteroid efficacy. The effect is less pronounced than with carbamazepine or phenytoin.
How serious is the interaction between Oxcarbazepine and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to prednisone and increase the dose if disease control worsens; reassess when oxcarbazepine is stopped.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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