Drug interactions
Oxcarbazepine + Propafenone
Severity: Minor
Oxcarbazepine and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine induces CYP3A4 and may reduce propafenone concentrations. This could lessen antiarrhythmic efficacy, although the extent is variable.
What this interaction means in plain words
Oxcarbazepine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxcarbazepine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Oxcarbazepine induction of CYP3A4 increasing propafenone metabolism.
What to do
Monitor arrhythmia control and ECG when oxcarbazepine is started or stopped. Increase propafenone dose if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Propafenone?
MediHelp rates the interaction as minor. Oxcarbazepine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine induces CYP3A4 and may reduce propafenone concentrations. This could lessen antiarrhythmic efficacy, although the extent is variable.
How serious is the interaction between Oxcarbazepine and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor arrhythmia control and ECG when oxcarbazepine is started or stopped. Increase propafenone dose if efficacy is lost.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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