Drug interactions
Oxcarbazepine + Roflumilast
Severity: Moderate
Oxcarbazepine and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weaker CYP3A4 inducer than carbamazepine but may still lower roflumilast exposure. This may reduce its benefit in COPD.
What this interaction means in plain words
Oxcarbazepine and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Roflumilast belongs to Respiratory.
Why it happens
Induction of CYP3A4 increases roflumilast clearance.
What to do
Monitor for loss of COPD control. Consider an alternative anticonvulsant or COPD therapy if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Roflumilast?
MediHelp rates the interaction as moderate. Oxcarbazepine and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weaker CYP3A4 inducer than carbamazepine but may still lower roflumilast exposure. This may reduce its benefit in COPD.
How serious is the interaction between Oxcarbazepine and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of COPD control. Consider an alternative anticonvulsant or COPD therapy if response declines.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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