Drug interactions
Oxcarbazepine + Sufentanil
Severity: Moderate
Oxcarbazepine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce sufentanil levels, weakening analgesia. If oxcarbazepine is stopped, sufentanil levels can rise and increase the risk of respiratory depression.
What this interaction means in plain words
Oxcarbazepine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by oxcarbazepine increases sufentanil metabolism.
What to do
Monitor analgesic response and respiratory status, and adjust the opioid dose when oxcarbazepine is started or withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Oxcarbazepine with Sufentanil?
MediHelp rates the interaction as moderate. Oxcarbazepine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce sufentanil levels, weakening analgesia. If oxcarbazepine is stopped, sufentanil levels can rise and increase the risk of respiratory depression.
How serious is the interaction between Oxcarbazepine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and respiratory status, and adjust the opioid dose when oxcarbazepine is started or withdrawn.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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