Drug interactions
Oxybutynin + Pilocarpine
Severity: Moderate
Oxybutynin and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist and oxybutynin is a muscarinic antagonist, so each can blunt the effect of the other. This may reduce the benefit of pilocarpine for dry mouth or of oxybutynin for bladder symptoms.
What this interaction means in plain words
Oxybutynin and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor efficacy of both drugs and avoid the combination when possible. Reassess the need for each agent if therapeutic response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Oxybutynin with Pilocarpine?
MediHelp rates the interaction as moderate. Oxybutynin and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist and oxybutynin is a muscarinic antagonist, so each can blunt the effect of the other. This may reduce the benefit of pilocarpine for dry mouth or of oxybutynin for bladder symptoms.
How serious is the interaction between Oxybutynin and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor efficacy of both drugs and avoid the combination when possible. Reassess the need for each agent if therapeutic response is lost.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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