Drug interactions
Oxybutynin + Rifapentine
Severity: Moderate
Oxybutynin and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and may substantially reduce oxybutynin concentrations, leading to loss of symptom control. The induction can persist for some time after rifapentine is stopped.
What this interaction means in plain words
Oxybutynin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Rifapentine belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by rifapentine increases first-pass and hepatic metabolism of oxybutynin.
What to do
Monitor for reduced efficacy and increase the oxybutynin dose if needed, or consider an alternative; reassess the dose after rifapentine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Oxybutynin with Rifapentine?
MediHelp rates the interaction as moderate. Oxybutynin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and may substantially reduce oxybutynin concentrations, leading to loss of symptom control. The induction can persist for some time after rifapentine is stopped.
How serious is the interaction between Oxybutynin and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy and increase the oxybutynin dose if needed, or consider an alternative; reassess the dose after rifapentine is discontinued.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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