Drug interactions
Oxybutynin + Secobarbital
Severity: Minor
Oxybutynin and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital induces CYP3A4 and may reduce oxybutynin levels. Additive sedation and cognitive effects are also possible with oxybutynin's central anticholinergic action.
What this interaction means in plain words
Oxybutynin and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxybutynin belongs to Genitourinary; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated CYP3A4 induction increases oxybutynin metabolism, with additive CNS depression.
What to do
Reassess oxybutynin efficacy and monitor for sedation or confusion, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Oxybutynin with Secobarbital?
MediHelp rates the interaction as minor. Oxybutynin and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secobarbital induces CYP3A4 and may reduce oxybutynin levels. Additive sedation and cognitive effects are also possible with oxybutynin's central anticholinergic action.
How serious is the interaction between Oxybutynin and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reassess oxybutynin efficacy and monitor for sedation or confusion, especially in older patients.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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