Drug interactions
Oxybutynin + Thioridazine
Severity: Moderate
Oxybutynin and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine has strong anticholinergic activity, so combining it with oxybutynin can markedly increase dry mouth, constipation, urinary retention and confusion. Thioridazine also prolongs the QT interval, and anticholinergic tachycardia adds to cardiac risk.
What this interaction means in plain words
Oxybutynin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Thioridazine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity and ECG as required for thioridazine. Prefer a non-anticholinergic bladder agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Oxybutynin with Thioridazine?
MediHelp rates the interaction as moderate. Oxybutynin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine has strong anticholinergic activity, so combining it with oxybutynin can markedly increase dry mouth, constipation, urinary retention and confusion. Thioridazine also prolongs the QT interval, and anticholinergic tachycardia adds to cardiac risk.
How serious is the interaction between Oxybutynin and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and ECG as required for thioridazine. Prefer a non-anticholinergic bladder agent.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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