Drug interactions
Oxybutynin + Tiotropium
Severity: Moderate
Oxybutynin and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combining them increases the risk of anticholinergic effects. These include dry mouth, constipation, urinary retention, blurred vision and, in older patients, confusion.
What this interaction means in plain words
Oxybutynin and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity, including cognitive effects in older adults. Consider a less anticholinergic bladder agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Oxybutynin
Frequently asked questions
Can I take Oxybutynin with Tiotropium?
MediHelp rates the interaction as moderate. Oxybutynin and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combining them increases the risk of anticholinergic effects. These include dry mouth, constipation, urinary retention, blurred vision and, in older patients, confusion.
How serious is the interaction between Oxybutynin and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, including cognitive effects in older adults. Consider a less anticholinergic bladder agent if symptoms develop.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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