Drug interactions
Oxybutynin + Verapamil
Severity: Minor
Oxybutynin and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 moderately and may increase oxybutynin concentrations, leading to more anticholinergic effects.
What this interaction means in plain words
Oxybutynin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxybutynin belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing oxybutynin metabolism.
What to do
Monitor for anticholinergic effects such as constipation and dry mouth, and reduce the oxybutynin dose if troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxybutynin and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxybutynin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Oxybutynin with Verapamil?
MediHelp rates the interaction as minor. Oxybutynin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP3A4 moderately and may increase oxybutynin concentrations, leading to more anticholinergic effects.
How serious is the interaction between Oxybutynin and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as constipation and dry mouth, and reduce the oxybutynin dose if troublesome.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
