Drug interactions
Oxybutynin + Ziprasidone
Severity: Minor
Oxybutynin and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision, and ziprasidone has only weak antimuscarinic activity, so any additive effect is modest. The combination can also add to sedation or dizziness in some patients.
What this interaction means in plain words
Oxybutynin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxybutynin belongs to Genitourinary; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive antimuscarinic and CNS depressant pharmacodynamic effects; ziprasidone's anticholinergic activity is weak.
What to do
Monitor for constipation, urinary retention, confusion and sedation, particularly in older patients. Reduce the oxybutynin dose or change therapy if anticholinergic effects become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Oxybutynin with Ziprasidone?
MediHelp rates the interaction as minor. Oxybutynin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision, and ziprasidone has only weak antimuscarinic activity, so any additive effect is modest. The combination can also add to sedation or dizziness in some patients.
How serious is the interaction between Oxybutynin and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention, confusion and sedation, particularly in older patients. Reduce the oxybutynin dose or change therapy if anticholinergic effects become troublesome.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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