Drug interactions
Oxymetholone + Tacrolimus
Severity: Moderate
Oxymetholone and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone may increase tacrolimus concentrations, raising the risk of nephrotoxicity and other adverse effects. Oxymetholone is itself hepatotoxic and may add to organ stress.
What this interaction means in plain words
Oxymetholone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible reduction of tacrolimus metabolism; the mechanism is not firmly established.
What to do
Monitor tacrolimus trough levels, renal function and liver tests, and adjust the tacrolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Oxymetholone with Tacrolimus?
MediHelp rates the interaction as moderate. Oxymetholone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxymetholone may increase tacrolimus concentrations, raising the risk of nephrotoxicity and other adverse effects. Oxymetholone is itself hepatotoxic and may add to organ stress.
How serious is the interaction between Oxymetholone and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels, renal function and liver tests, and adjust the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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