Drug interactions
Oxymorphone + Rasagiline
Severity: Major
Oxymorphone and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with MAO inhibitors, including rasagiline, can cause additive CNS depression, hypotension and rarely serotonergic reactions. Oxymorphone labeling advises avoiding use within 14 days of MAOI therapy.
What this interaction means in plain words
Oxymorphone and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxymorphone belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition may potentiate opioid CNS and autonomic effects; mechanism incompletely defined.
What to do
Avoid the combination and use an alternative analgesic where possible. If unavoidable, begin with a low oxymorphone dose and monitor sedation, blood pressure and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Oxymorphone with Rasagiline?
MediHelp rates the interaction as major. Oxymorphone and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with MAO inhibitors, including rasagiline, can cause additive CNS depression, hypotension and rarely serotonergic reactions. Oxymorphone labeling advises avoiding use within 14 days of MAOI therapy.
How serious is the interaction between Oxymorphone and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative analgesic where possible. If unavoidable, begin with a low oxymorphone dose and monitor sedation, blood pressure and signs of serotonin toxicity.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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